Preliminary Phytochemical Screening and Acute Toxicity Study of Methanol leaf extracts of Musanga cercropioides

T. O. Okugbo; Ufuoma Shemishere; Clement Boniface Gomo; Faith Aghayere; Oghenevwede Erhovwosere; Judith Taiwo; Grandy Austin Jaboro

doi:10.62050/ljsir2024.v2n1.164

المؤلفون

T. O. Okugbo
Department of Medical Biochemistry, College of Medical Sciences, Benson Idahosa University, Benin City, Edo State
Ufuoma Shemishere
shemishere.ufuoma@fubk.edu.ng

Department of Biochemistry and Molecular Biology, Federal University Birnin Kebbi
https://orcid.org/0000-0001-9593-8779
Clement Boniface Gomo
Department of Biochemistry and Molecular Biology, Federal University Birnin Kebbi
Faith Aghayere
Department of Biochemistry, University of Benin, Benin City
Oghenevwede Erhovwosere
Department of Biochemistry, University of Benin, Benin City
Judith Taiwo
Department of Biochemistry, University of Benin, Benin City
Grandy Austin Jaboro
Precious Life Medical Center, Kaura District, Abuja, FCT

الكلمات المفتاحية:

Musanga cercropioides , Methanol extracts , Phytochemicals , Toxicity , Lethal Dose 50

الملخص

Musanga cercropioides is a plant that is used to treat a variety of ailments in many African countries. However, just a few studies have been conducted to assess the toxicity of the various sections of this plant. The goal of this study was to determine the toxicity profile of Musanga cercropioides methanol leaf extract in albino rats. Lorke's approach was used to conduct an acute toxicity study. In the first phase, nine (9) albino rats were randomly divided into three (3) groups of three (3) animals each. Each of the animals were orally administered 10,100 and 1000 mg/kg body weight of the extract. In the second phase, twelve (12) animals were used, which were divided into four groups of three (3) animals each. The first three groups received single doses of 1500, 3000, and 5000 mg/kg, respectively, while the fourth group which served as a control was given distilled water orally. After observation for 14 days, no signs of mortality were identified. The maximum dose supplied (5000 mg/kg body weight) did not affect the test animals' mortality or general behavior. When the treated groups were compared to the control groups, there was no significant difference (p > 0.05) in biochemical markers, body weight, or relative organ weights of liver, kidney, heart, and spleen. These findings show that oral administration of Musanga cercropioides methanol leaf extract is safe at a dose of up to 5000 mg/kg body weight in Wistar albino rats.

Dimensions

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